![TBK1 recruitment to STING activates both IRF3 and NF-κB that mediate immune defense against tumors and viral infections | PNAS TBK1 recruitment to STING activates both IRF3 and NF-κB that mediate immune defense against tumors and viral infections | PNAS](https://www.pnas.org/cms/10.1073/pnas.2100225118/asset/c26a5f41-d400-4a08-a4b5-9f2265714777/assets/images/large/pnas.2100225118fig02.jpg)
TBK1 recruitment to STING activates both IRF3 and NF-κB that mediate immune defense against tumors and viral infections | PNAS
Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-κB Signaling Adaptation
![TBK1 recruitment to STING activates both IRF3 and NF-κB that mediate immune defense against tumors and viral infections | PNAS TBK1 recruitment to STING activates both IRF3 and NF-κB that mediate immune defense against tumors and viral infections | PNAS](https://www.pnas.org/cms/10.1073/pnas.2100225118/asset/db848d79-1de7-4bc4-bde9-b07b4a767884/assets/images/large/pnas.2100225118fig05.jpg)
TBK1 recruitment to STING activates both IRF3 and NF-κB that mediate immune defense against tumors and viral infections | PNAS
![Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-κB Signaling Adaptation - ScienceDirect Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-κB Signaling Adaptation - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S2211124719304371-gr4.jpg)
Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-κB Signaling Adaptation - ScienceDirect
![TBK1 and IKKε Act Redundantly to Mediate STING-Induced NF-κB Responses in Myeloid Cells - ScienceDirect TBK1 and IKKε Act Redundantly to Mediate STING-Induced NF-κB Responses in Myeloid Cells - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S2211124720303703-fx1.jpg)
TBK1 and IKKε Act Redundantly to Mediate STING-Induced NF-κB Responses in Myeloid Cells - ScienceDirect
![Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-κB Signaling Adaptation - ScienceDirect Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-κB Signaling Adaptation - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S2211124719304371-gr3.jpg)
Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-κB Signaling Adaptation - ScienceDirect
![Innate immune response orchestrates phosphoribosyl pyrophosphate synthetases to support DNA repair - ScienceDirect Innate immune response orchestrates phosphoribosyl pyrophosphate synthetases to support DNA repair - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S1550413121003259-fx1.jpg)
Innate immune response orchestrates phosphoribosyl pyrophosphate synthetases to support DNA repair - ScienceDirect
Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-κB Signaling Adaptation
Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-κB Signaling Adaptation
![Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-κB Signaling Adaptation - ScienceDirect Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-κB Signaling Adaptation - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S2211124719304371-gr2.jpg)
Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-κB Signaling Adaptation - ScienceDirect
Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-κB Signaling Adaptation
Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-κB Signaling Adaptation
![Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-κB Signaling Adaptation - ScienceDirect Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-κB Signaling Adaptation - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S2211124719304371-gr1.jpg)
Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-κB Signaling Adaptation - ScienceDirect
![Engineering the Immune Adaptor Protein STING as a Functional Carrier - Sun - 2021 - Advanced Therapeutics - Wiley Online Library Engineering the Immune Adaptor Protein STING as a Functional Carrier - Sun - 2021 - Advanced Therapeutics - Wiley Online Library](https://onlinelibrary.wiley.com/cms/asset/3122bcd6-da9c-4e9d-95cb-6447008f1862/adtp202100066-fig-0002-m.jpg)
Engineering the Immune Adaptor Protein STING as a Functional Carrier - Sun - 2021 - Advanced Therapeutics - Wiley Online Library
![Frontiers | Inhibitory targeting cGAS-STING-TBK1 axis: Emerging strategies for autoimmune diseases therapy Frontiers | Inhibitory targeting cGAS-STING-TBK1 axis: Emerging strategies for autoimmune diseases therapy](https://www.frontiersin.org/files/Articles/954129/fimmu-13-954129-HTML-r1/image_m/fimmu-13-954129-g002.jpg)
Frontiers | Inhibitory targeting cGAS-STING-TBK1 axis: Emerging strategies for autoimmune diseases therapy
![TBK1 recruitment to STING activates both IRF3 and NF-κB that mediate immune defense against tumors and viral infections | PNAS TBK1 recruitment to STING activates both IRF3 and NF-κB that mediate immune defense against tumors and viral infections | PNAS](https://www.pnas.org/cms/10.1073/pnas.2100225118/asset/a7033003-7eb9-468c-81fa-597f27b1856d/assets/images/large/pnas.2100225118fig01.jpg)
TBK1 recruitment to STING activates both IRF3 and NF-κB that mediate immune defense against tumors and viral infections | PNAS
![GRA15 promotes activation of STING. A, Diagram detailing STING domains... | Download Scientific Diagram GRA15 promotes activation of STING. A, Diagram detailing STING domains... | Download Scientific Diagram](https://www.researchgate.net/publication/335206332/figure/fig3/AS:792502516858881@1565958732688/GRA15-promotes-activation-of-STING-A-Diagram-detailing-STING-domains-CBD-and-CTT-and.jpg)
GRA15 promotes activation of STING. A, Diagram detailing STING domains... | Download Scientific Diagram
![Transcription-independent regulation of STING activation and innate immune responses by IRF8 in monocytes | Nature Communications Transcription-independent regulation of STING activation and innate immune responses by IRF8 in monocytes | Nature Communications](https://media.springernature.com/m685/springer-static/image/art%3A10.1038%2Fs41467-022-32401-1/MediaObjects/41467_2022_32401_Fig1_HTML.png)